A model showing how metallic bonds are formed - the first diagram shows the outer electrons in their atoms, and the second diagram shows that the electrons have become delocalised ...

and a trial of one regimen – the combination of AZ's A2A drug AZD4635 and a CD73 blocking agent called oleclumab – was abandoned last year after disappointing results in lung cancer.

因此，阻断CD73可以增强免疫细胞的抗肿瘤作用。目前阿斯利康的Oleclumab处于领先地位，此外，BMS和诺华也曾开发CD73单抗，但BMS的管线进展缓慢，诺华的管线则已终止。 据了解，CD73单抗本身存在局限性，需要与其他药物（如PD-1单抗）联用才能发挥较好效果 ...