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药物非临床研究优选体外代谢模型——微粒体
其中肺 P450 酶在对异物的生物转化及吸入的化学致癌物的失活和肺毒素的解毒方面发挥了重要的作用。 综上所述,药物的体内代谢通常经由多种器官、多种酶系协同完成,因此,作为药物申报的非临床早研阶段,选择合适的体外模型对于了解的药物的代谢途径或 ...
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