A 1:200 dilution of the p53-Ab-1 antibody (Oncogene) was used for immunofluorescence of p53 and a 1:200 dilution of the PCNA-Ab-1 antibody (Oncogene) was used to detect proliferating cell nuclear ...

This study presents important findings on the activity of two compounds, BKC and IBC, isolated from Psoralea corylifolia, which act synergistically to inhibit cancer cell proliferation. Using a ...

The data provide solid evidence that Srs2 interaction with PCNA and ensuing SUMO modification is required for checkpoint downregulation. However, while the model that Srs2 acts at gaps after ...

Following the loading of PCNA by RFC, DNA polymerase-δ and -ɛ take over DNA synthesis 29. PCNA interacts with the DNA polymerases (Fig. 2) and markedly increases their processivity. It should be ...

During genome replication, replication forks often encounter obstacles that impede their progression. Arrested forks are unstable structures that can give rise to collapse and rearrange if they are ...

The Fanconi anemia (FA) pathway is a major mechanism of homologous recombination DNA repair. The functional readout of the pathway is activation through mono-ubiquitination of FANCD2 leading to ...