Adjuvant treatment with 160 mg aspirin daily for three years cuts recurrence rates in patients with colorectal cancer with ...

Low-dose aspirin reduced colorectal cancer (CRC) recurrence rates by more than half in patients with tumors harboring mutations in the PI3K signaling pathway, according to findings from the phase ...

通过比较分析286例IDH-wildtype而IDH-mutant较低品位的神经胶质瘤TCGA从一个数据集,我们报告IDH-mutant神经胶质瘤肿瘤控制基因的表达增加(NF1、PTEN和PIK3R1)和减少致癌基因的表达(AKT2, ARAF, ERBB2、FGFR3 PDGFRB)和神经胶质瘤进展基因(FOXM1、IGFBP2 WWTR1)而IDH-wildtype神经胶质瘤。

Aspirin reduced disease recurrence in patients PI3K-mutated colorectal cancer, underscoring the value of early genomic ...

“Aspirin has been shown to effectively reduce recurrence rates and improve disease-free survival,” said Anna Martling, MD, PhD. In patients with PIK3CA alterations in exon 9 and/or 20, the ...

“The old adage ‘take two aspirin and call me in the morning’ may now find a new meaning. A simple intervention of low-dose aspirin reduces the risk of colorectal cancer recurrence for patients with ...

This study provides convincing data showing that expression of the PIK3R1(deltaExon11) dominant negative mutation in Activated PI3K Delta Syndrome 1/2 (APDS1/2) patient-derived cells reduces AKT ...

The authors identify new mechanisms that link a PIK3R1 mutant to cellular signaling and division in Activated PI3 Kinase Delta Syndrom 1 and 2 (APDS1/2). The conclusion that this mutant serves as a ...

Patients with adenomyosis not only experience a decrease in quality of life as a result of dysmenorrhea and severe monthly flow but they are also rendered infertile. Pregnancy rates are still low ...