Disinfectants induce oxidative damage in bacteria, but a single mutation triggers the expression of genes that help the ...

This manuscript provides important structural insights into the recognition and degradation of the host tRNA methyltransferase TRMT1 by SARS-CoV-2 protease nsp5 (Mpro). The data provide compelling ...

Department of Chemistry, University of California, Berkeley, California 94720, United States Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, United ...

2018). However, reports about mt-ncRNA modifications are absent at present, because mt-ncRNAs are not well identified yet. mt-tRNA modifications are essential for their normal functions. Modifications ...

IN view of the increasing importance of anhydro-N-carboxyamino-acids for the synthesis of polypeptides 1,2, it is pertinent to report the following simple preparation of compounds of this type.

RESULTS A novel heteroplasmic mitochondrial DNA mutation was identified in the transfer RNA gene for phenylalanine in one case (patient 3). This mutation was not detected in the patient’s blood or in ...

Center for Proteomics & Artificial Intelligence, Allegheny Health Network Cancer Institute, Pittsburgh, Pennsylvania 15205, United States Center for Clinical Mass Spectrometry, Allegheny Health ...

如果没有防御机制，聚球菌很可能会因为Syn9等噬菌体的威胁而灭绝。以色列理工学院研究人员的研究描述了一种进化情景，其中保护来自tRNA（转移RNA）水平的降低，tRNA是一种对基因翻译至关重要的分子。 林德尔教授解释说：“对耐药性的研究通常集中在提供 ...

Phenylketonuria (PKU) is a genetic metabolic disorder that increases levels of the essential amino acid known as phenylalanine in the blood. People with PKU are unable to metabolize phenylalanine ...