Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed Tumor M2 pyruvate kinase. In the last few years, much attention has been paid to this novel ...

SL1009 is expected to increase energy production by inhibiting pyruvate dehydrogenase kinase and stimulating residual pyruvate dehydrogenase complex activity. The NDA is supported by data from a ...

The Change Reaction founder Greg Perlman discusses how they’re working to help the community impacted by the California wildfires on ‘Fox News @ Night.’ ...

Sarah Vine and Andrew Pierce bring their own no-holds-barred opinions, insights and reaction (clue is in the title) to the biggest stories of the week. New episodes every Wednesday, wherever you ...

An aliquot of the sample was incubated with DCFH-DA (100 μM) at 37°C for 30 min. The reaction was terminated by chilling the reaction mixture in ice. The formation of the oxidized fluorescent ...

For example, 45 human protein kinases lack at least one of the conserved catalytic residues 2 and may not have kinase activity. Kinase activity has not been detected for several CDK-related ...