HIV-1 reverse transcriptase inhibitors are crucial components in the treatment of HIV, a virus that leads to acquired immune deficiency syndrome (AIDS). These inhibitors are categorized into two ...

Generally, the dual NRTI backbone treatment of combination with a non-NRTI (NNRTI) or protease inhibitor (PI) should comprise a cytidine analogue (lamivudine, emtricitabine) and a thymidine ...

Summary: While single mutations confer resistance to earlier nonnucleoside reverse transcriptase inhibitors (NNRTIs), etravirine exhibited an increased barrier to resistance by requiring multiple ...

Analysts at RBC Capital Markets have predicted twice-yearly lenacapavir could become a $2 billion product, and become a key ...

A substance that acts against retroviruses such as HIV. There are several classes of antiretrovirals, which are defined by what step of viral replication they target: nucleoside reverse transcriptase ...

Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States ...

Conclusion: ACL inhibitor BMS-303141 protects against obesity-related renal injuries ... In a 20 μL reaction volume, the first strand of complementary DNA (cDNA) was produced from equal quantities of ...

Memory decline and social functional impairment are common manifestations of accelerated aging in PD. The function of telomerase reverse transcriptase (TERT) and telomere length (TL) is abnormal in ...

Welcome to the Merck & Company Q4 sales and earnings conference call. [Operator instructions] This call is being recorded. [Operator instructions] I would now like to turn the call over to Mr. Peter ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

Goran13 / Getty Images Reverse mortgages are a way for homeowners 62 years and older to draw an income (either in installments, a lump sum, or a credit line) against the equity they have built up ...

Furin is identified as the key enzyme responsible for cleaving the apelin precursor. Inhibiting this cleavage could serve as ...