This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

phosphoinositide 3-kinase; SQSTM1, sequestosome 1/p62; ULK1, Unc-51 like autophagy activating kinase 1. Future research should focus on clarifying the dual role of HSF1 in autophagy regulation, ...

We also demonstrate that the autophagic target SQSTM1/p62 is decreased in SOD1-G93A microglia after a short stimulation of P2X7, but increased after a sustained challenge. These effects are prevented ...