【导读】TREM2是一种主要在髓样细胞表面表达的受体，是病理诱导免疫信号传导中的一个主要枢纽基因。然而，其在肝细胞癌（HCC）中的功能仍存在争议。1月21日，新疆石河子大学研究团队在期刊《Journal of Experimental & ...

Emerging evidence suggests a role for PI3K/mTOR signalling in the pathology of organ fibrosis. The aim of this study was to delineate PI3K/mTOR signalling in response to TGF-β 1 stimulation of primary ...

Secreting CXCLs, ILs, TGF-β, CCL12, PGE2, CAFs promote pro-cancer macrophage conversion, inactivate NK cells, and hinder CD8+T cell aggregation. Immune cells like TAMs, NKs, CD8+Ts, MCs ...

The primary node molecules in the cell signaling network in cancer tissues are maladjusted and mutated in comparison to normal tissues, which promotes the occurrence and progression of cancer.

Mission Statement: Evidence-based Complementary and Alternative Medicine (eCAM) is an international, peer-reviewed journal that seeks to understand the sources and to encourage rigorous research ...

IL-1 activity on both DCs and T cells can further shape the adaptive immune response with variable outcomes. IL-1 signaling in DCs promotes their ability to induce T cell activation, but also direct ...

From the Centers of Inflammation, Translational, and Clinical Lung Research (Y. Shao, Y. Sun, Y.L., F.S., C.D., C.J., K.X., X.J., X.Y.), Temple University, Lewis Katz ...

2009;4(1):105-118. Eh arginase Converts L-arginine, the precursor of NO, into L-ornithine and thus hinders NO production in the macrophage [29] β1 integrin-like receptors Interact with ...

Maja Jagodic is Professor of Neuroinflammation, Associate Professor in Experimental Medicine, and research group leader for research on epigenetics of Multiple Sclerosis at the Department of Clinical ...