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Figure 1: Domain structure of ubiquitin-specific proteases. DUB activities fall into three major functional categories (Fig. 3). First, ubiquitin can be transcribed from several genes as a linear ...

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PLCγ binds to NPM–ALK directly, and this association is mediated by the SH2 domain of PLCγ and the Tyr664 residue of NPM–ALK. Mouse Ba/F3 lymphoid cells and Rat1a fibroblasts transfected ...

Figure 2. Regulation of PD-L1 by DUBs. A schematic illustration of multiple DUBs involved in PD-L1 deubiquitylation, including USP22, CSN5, and USP9X. ICD, intracellular domain; TM, transmembrane ...

Sphingosine kinase 1(SphK1) a key enzyme that catalyzes the conversion of sphingosine (Sph) to sphingosine 1-phosphate (S1P), so as to maintain the dynamic balance of sphingolipid-rheostat in cells ...