Eukaryotic cells exposed to DNA damaging agents also activate important defensive pathways by inducing multiple proteins involved in DNA repair, cell cycle checkpoint control, protein …

DNA repair proteins, such as DNA-dependent protein kinase (DNA-PK), Ku, and ataxia-telangiectasia-mutated (ATM), have been linked to cellular DNA repair pathways that work to …

2024年1月24日 · Identifying potential drug candidates for treating and studying the interactions between proteins involved in DNA repair processes, such as simulating the interactions …

Classification of proteins from the DNA repair processes according to the DNA damaging agents, the type of DNA damage in relation with recruited effectors, repair mechanisms, and cell cycle …

As described previously, the major proteins involved with DNA repair include sensory (DNA binding) proteins, enzymes that remove damaged bases, and enzymes that restore the normal …

2023年7月25日 · Mismatch repair proteins correct this by locating incorrectly matched nucleotides and excising them before placing the correct nucleotide in its place. Exogenous damage, also …

2023年2月13日 · To preserve genomic integrity, cells have an arsenal of repair proteins that engage the appropriate repair pathway or, if damage is irreparable, induce cell cycle arrest …

Guarding genes against damage is a crucial and complex job, so it’s to be expected that cells have several mechanisms to repair DNA breakages, each providing support under different...

2017年12月20日 · Here, we will describe the five main mechanisms by which DNA avoids mutation, namely the processes of base excision repair, mismatch repair, nucleotide excision …

DNA repair proteins act to correct mutagenic and toxic DNA damage, which can lead to cancer, aging and death. These proteins and their mechanisms of action have been found to be widely …