2024年11月21日 · In this study, we address this technological gap by presenting a detailed analysis of DSB repair factor localization in single cells. We use two methods to map DNA …

DNA repair proteins, such as DNA-dependent protein kinase (DNA-PK), Ku, and ataxia-telangiectasia-mutated (ATM), have been linked to cellular DNA repair pathways that work to …

2024年1月24日 · A database called DNArepairK tracks the kinetics of 70 fluorescently titled DNA repair proteins’ recruitment and clearance from complicated DNA damage sites in vivo in HeLa …

As described previously, the major proteins involved with DNA repair include sensory (DNA binding) proteins, enzymes that remove damaged bases, and enzymes that restore the normal …

2022年2月4日 · We review the current knowledge of C. elegans DNA repair, recombination, and DNA damage response pathways, and their role during development, growth, and in the germ …

2023年2月13日 · To preserve genomic integrity, cells have an arsenal of repair proteins that engage the appropriate repair pathway or, if damage is irreparable, induce cell cycle arrest …

1995年2月1日 · DNA repair proteins act to correct mutagenic and toxic DNA damage, which can lead to cancer, aging and death. These proteins and their mechanisms of action have been …

2017年12月20日 · Here, we will describe the five main mechanisms by which DNA avoids mutation, namely the processes of base excision repair, mismatch repair, nucleotide excision …

Guarding genes against damage is a crucial and complex job, so it’s to be expected that cells have several mechanisms to repair DNA breakages, each providing support under different...

2023年7月25日 · DNA repair is crucial to correcting the mistakes our replicative machinery makes when forming new materials within our bodies. Damage to DNA molecules, if left unrepaired, …