2022年10月17日 · Relaxin is a reproductive hormone produced by your ovaries and the placenta. It loosens and relaxes your muscles, joints and ligaments during pregnancy to help your body stretch. Relaxin also helps your body prepare for delivery …

2023年1月18日 · The relaxin hormone, made by your ovary and placenta during pregnancy, relaxes ligaments and widens the cervix. This hormone plays an important role during pregnancy as well as in your menstrual...

Relaxin is a hormone produced by the ovary and the placenta with important effects in the female reproductive system and during pregnancy. In preparation for childbirth, it relaxes the ligaments in the pelvis and softens and widens the cervix.

Relaxin was discovered in 1926 in pregnant guinea pigs. It was shown to cause the pelvic ligaments to relax, allowing the body to accommodate the strain of pregnancy and ease the passage of offspring through the birth canal.

Relaxin has beneficial effects upon the endometrium which are responsible for establishment of pregnancy. We have demonstrated that relaxin stimulates endometrial decidualization, the structural and biochemical changes in endometrial parenchymal ...

Relaxin is a hormone structurally related to insulin and insulin-like growth factor, which exerts its regulatory effect on the musculoskeletal and other systems through binding to its receptor in various tissues, mediated by different signaling ...

2024年8月6日 · Relaxin is a protein-based hormone usually secreted by the corpus luteum (which is a hormone-producing structure) in the ovary. Relaxin hormone is found both in men and non-pregnant women. In men, the prostate gland secretes the relaxin hormone in their bodies.

Relaxin given to humans is safe and produces favourable haemodynamic changes. Serelaxin, the recombinant form of relaxin, is now in extended phase III clinical trials for the treatment of acute heart failure.

Relaxin is a vasoactive peptide hormone encoded by the human relaxin genes RLN1 and RLN2 (producing H1 and H2 relaxin, respectively). By binding to the relaxin family peptide receptor (RXFP), relaxin exerts its actions through G-protein-coupled signalling and downstream mediators including cyclic AMP (cAMP), mitogen activated protein kinases ...

‘Relaxin’ (designated relaxin-2, or H2 relaxin in humans) is largely characterised as a peripheral hormone that plays vital physiological roles in pregnant mammals, such as promoting growth and softening of the cervix and the development of the mammary apparatus (Sherwood, 2004).