Reactive astrocyte nomenclature, definitions, and future directions
2021年2月15日 · Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS.
Reactive Astrocytes: Production, Function, and Therapeutic Potential
2017年6月20日 · In this review, we summarize recent studies that demonstrate that different initiating CNS injuries can elicit at least two types of "reactive" astrocytes with strikingly different properties, one type being helpful and the other harmful.
Reactive Astrocytes: Production, Function, and Therapeutic …
2017年6月20日 · In this review, we summarize recent studies that demonstrate that different initiating CNS injuries can elicit at least two types of “reactive” astrocytes with strikingly different properties, one type being helpful and the other harmful.
Reactive astrocyte nomenclature, definitions, and future directions
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and ...
Functional roles of reactive astrocytes in neuroinflammation and ...
2023年6月12日 · In this Review, we highlight how single-cell and single-nuclei RNA sequencing and other ‘omics’ technologies can enable the functional characterization of defined reactive astrocyte states in...
Neurotoxic reactive astrocytes are induced by activated microglia
2017年1月18日 · Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease, but their role is poorly understood. Here we show that a subtype of reactive astrocytes, which we...
Reactive astrocytes: The nexus of pathological and clinical …
In this review, we use a holistic approach to incorporate, and expand upon, classic neuroinflammatory concepts to consider how astrocyte dysfunction/reactivity modulates multiple pathological and clinical hallmarks of AD.
In this review, we summarize recent studies that demonstrate that different initiating CNS injuries can elicit at least two types of ‘‘reactive’’ astrocytes with strikingly different properties, one type being helpful and the other harmful.
Astrocyte reactivity: Subtypes, states and functions in CNS innate ...
Here, we discuss the goal of differentiating reactive astrocyte subtypes and states based on composite pictures of molecular expression, cell morphology, cellular interactions, proliferative state, normal functions and disease-induced dysfunctions.
Astrocyte Reactivity: Subtypes, States, and Functions in CNS …
This review discusses the goal of differentiating reactive astrocyte subtypes and states based on composite pictures of molecular expression, cell morphology, cellular interactions, proliferative state, normal functions, and disease-induced dysfunctions.