2023年11月12日 · Mechanism of Action. Amiodarone belongs to the class III antiarrhythmic drugs. Similar to other drugs in this class, the primary mechanism of amiodarone involves the inhibition of potassium rectifier currents responsible for repolarizing the heart during phase 3 of the cardiac action potential.

Mechanism of action. Amiodarone is considered a class III anti-arrhythmic drug. It blocks potassium currents that cause repolarization of the heart muscle during the third phase of the cardiac action potential. As a result amiodarone increases the duration of the action potential as well as the effective refractory period for cardiac cells ...

2024年5月20日 · Amiodarone is used to treat ventricular tachycardia or ventricular fibrillation. Amiodarone is for use only in treating life-threatening heart rhythm disorders. Amiodarone can cause dangerous side effects on your heart, liver, lungs, or vision.

The mechanisms of action of amiodarone include blocking potassium ion channels (prolonging repolarization), blocking sodium ion channels, and antagonizing alpha- and beta-adrenergic receptors. [13] The action of amiodarone can be characterized by the following effects: [ 13 ]

2020年2月17日 · Class III antiarrhythmic agent which inhibits adrenergic stimulation (alpha- and beta-blocking properties), affects sodium, potassium, and calcium channels, prolongs the action potential and refractory period in myocardial tissue; decreases AV conduction and sinus node function. Oral: Slow and variable.

AMIODARONE (a MEE oh da rone) prevents and treats a fast or irregular heartbeat (arrhythmia). It works by slowing down overactive electric signals in the heart, which stabilizes your heart rhythm. It belongs to a group of medications called antiarrhythmics.

Amiodarone, a potent antiarrhythmic medication with a complex pharmacological profile, has emerged as a pivotal therapeutic agent in the management of various cardiac arrhythmias, prompting extensive research into its mechanisms of action, clinical efficacy, and potential adverse effects [1].

2025年1月8日 · Like class I drugs, amiodarone blocks sodium channels at rapid pacing frequencies, and like class II drugs, amiodarone exerts a noncompetitive antisympathetic action. One of its main effects, with prolonged administration, is to lengthen the cardiac action potential, a …

2024年3月12日 · Amiodarone is a potent Class 3 antiarrhythmic drug with a broad spectrum of action, making it useful for treating a variety of arrhythmias. However, its complex pharmacokinetics and potential for toxicity require careful monitoring and consideration of …

2024年6月10日 · Used during cardiac arrest for treatment of refractory (i.e., unresponsive to CPR, defibrillation, and a vasopressor [e.g., epinephrine]) VF or pulseless VT. Considered the preferred antiarrhythmic drug for this use in current ACLS guidelines in adults; lidocaine may be …