Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1…
2016年9月17日 · Mechanistically, pharmacological activation of SIRT1 improved adult neurogenesis in the DG together with an enhanced performance of cx3cr1 −/− mice in a …
Metabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 …
2025年1月9日 · In this study, we discovered that SIRT1 promotes the upregulation of CX3CL1 in CRC cells. CX3CL1, in turn, enhances the function of Tregs and suppresses antitumor …
Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1…
2016年9月17日 · Here we report that microglia in the dentate gyrus (DG) of cx3cr1 (-/-) mice displayed elevated microglial sirtuin 1 (SIRT1) expression levels and nuclear factor kappa-light …
Modulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal ...
2021年12月14日 · Our study reveals a potential novel mechanism of SIRT1-mTORC1 pathway in microglia regulation, and indicates a therapeutic potential for the protection of RGCs in ONI. …
Modulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal ...
2021年12月14日 · The response of microglia has emerged as an impactful component of etiology in neurodegeneration. This study aimed to investigate the effect of SIRT1-mTORC1 signaling …
Microglial CX(3)CR1 promotes adult neurogenesis by inhibiting Sirt 1 …
Here we report that microglia in the dentate gyrus (DG) of cx3cr1 (-/-) mice displayed elevated microglial sirtuin 1 (SIRT1) expression levels and nuclear factor kappa-light-chain-enhancer of …
(PDF) Microglial CX3CR1 promotes adult neurogenesis by
2016年9月17日 · Activation of microglial SIRT1 increases proliferation of DCX + cells in cx3cr1 −/− mice and improves spatial learning and memory. a Immunohistochemistry in DG reveals …
The involvement of microglial CX3CR1 in heat acclimation ... - PubMed
Microglial CX3C chemokine receptor 1 (CX3CR1) has been implicated in numerous cellular mechanisms, including signalling pathways that regulate brain homoeostasis and adult …
小胶质细胞CX3CR1通过抑制独立于CX3CL1的Sirt 1 / p65信号传导 …
在这里我们报告cx3cr1（-/-）小鼠的齿状回（DG）中的小胶质细胞显示出升高的小胶质瑟土因1（SIRT1）表达水平和核因子kappa轻链增强的活化B细胞（NF-kB）p65激活，尽管 …
Microglial SIRT1 activation attenuates synapse loss in retinal inner ...
2023年9月5日 · Resveratrol and EX527, highly specific activator and inhibitor of SIRT1, respectively, were used to explore the function of SIRT1 in vivo and vitro. Cx3Cr1 …