Prior to secreting any of the bile acids (primary or secondary, see below), liver cells conjugate them with either glycine or taurine, to form a total of 8 possible conjugated bile acids. These …

2023年5月1日 · Bile acids get conjugated in the liver to increase their water solubility because bile salts have a decreased pK, which favors the basic anionic form in the acidic duodenum. As …

The primary bile acids are then conjugated to glycine, taurine (particularly in cats), glucuronic acid and sulfates within the hepatocyte and excreted into bile canaliculi via the bile salt export …

Conjugated bile acids are water-soluble, amphipathic, membrane-impermeable end products of cholesterol metabolism. The major functions of bile acids in the liver, biliary tract, and small …

In higher vertebrates, C 24 bile acids constitute a major part of the bile, and in human bile, these compounds are almost completely in conjugated form with either glycine (75%) or taurine …

Conjugated bile acids are secreted into bile via the canalicular bile salt export pump (BSEP), forming mixed micelles with cholesterol and phosphatidylcholine in the gallbladder to prevent …

Before their secretion into the bile canalicular lumen for storage in the gallbladder as mixed micelles with phospholipids and cholesterol, primary bile acids are conjugated with taurine or …

Conjugated bile acids are known inhibitors of the ligase (Vessey and Zakim 1977), and are hypothesized to regulate the rate of bile acid conjugation by virtue of their enterohepatic …

2017年9月25日 · Conjugated bile acids are then retaken up by hepatocytes via the sodium taurocholate cotransporter (NTCT), while unconjugated bile acids are taken up by organic …

2017年9月25日 · The reabsorbed bile acids are transported to the liver in portal blood. Conjugated bile acids are then retaken up by hepatocytes via the sodium taurocholate …