2022年10月30日 · Glutathione peroxidase 4 (GPX4) acts as a master regulator in the ferroptosis process, and its unique function is to interrupt lipid peroxidation by converting lipid …

Genetic studies performed in cells and mice established the selenoenzyme glutathione peroxidase (GPX4) as the key regulator of this form of cell death.

2024年5月1日 · GPX4 is closely associated with ferroptosis and functions as the primary inhibitor of this process. Together, GPX4 and ferroptosis contribute to the pathophysiology of several …

2023年3月30日 · Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase that powerfully inhibits lipid oxidation. In the past years, it is considered as a key …

1 天前 · Fig. 1: PKA suppresses ferroptosis. Fig. 2: GPX4 is a critical regulator for PKA-dependent ferroptosis. PKA, activated by cAMP, transduces signaling to downstream effectors through …

2019年3月1日 · A phenotypic screening campaign in cells undergoing Gpx4 knockout-induced ferroptosis led to the identification of liproxstatin-1 as the first in vivo efficacious ferroptosis …

Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of ferroptosis, …

GPX4 is closely associated with ferroptosis and functions as the primary inhibitor of this process. Together, GPX4 and ferroptosis contribute to the pathophysiology of several diseases, …

5 天之前 · A highly selective ferroptosis inducer with drug-like properties can significantly advance the research on inducing ferroptosis for anticancer treatment. We previously reported a highly …

These data suggest that DHODH inhibition induces ferroptosis in GPX4-low cancer cells while sensitizing GPX4-high cancer cells to ferroptosis. Sulfasalazine can inhibit system xc, so the …