2019年9月25日 · In the last ten years, biosynthetic gene clusters of several nucleoside antibiotics have been identified, and unique biosynthetic mechanisms have been elucidated. These developments have made...

2015年2月1日 · Biosynthesis of complex nucleoside antibiotics proceeds via multiple steps from simple building blocks of nucleosides, amino acids, sugars, and fatty acids. The nucleoside is modified to constitute the core skeleton that distinguishes the different groups of …

Nucleoside antibiotics are a large family of natural products with diverse biological functions. Their biosynthesis is a complex process through multistep enzymatic reactions and is subject to hierarchical regulation.

2015年2月1日 · Biosynthesis of nucleoside antibiotics is regulated at multiple levels. Biosynthetic studies may assist with rational design of novel antibacterial agents. The alarming rise in antibiotic-resistant pathogens has coincided with a decline in the supply of new antibiotics.

Genetic and biochemical studies of the biosyn-thetic machinery have provided the basis for pathway engineering and combinatorial biosynthesis to create new or hybrid nucleoside antibiotics. Dissection of reg-ulatory mechanisms is leading to strategies to increase the titer of bioactive nucleoside antibiotics.

2022年1月4日 · In this review, we mainly summarize the recent advances on the biosynthesis of C-nucleoside antibiotics, and we also tentatively discuss the future developments on rationally accessing C-nucleoside diversities in a more efficient and economical way via …

As with the numerous other analog types that have been isolated from microorganisms, these nucleoside analogs have also been useful biochemical probes in the elucidation of the complex steps of RNA, DNA, protein, and cell wall synthesis as well as cytoplasmic, mitochondrial, and nuclear processes.

2016年3月1日 · Understanding how nature builds this family of antibiotics in post-genomic era sets the stage for rational enhancement of their production, and also paves the way for targeted persuasion of the cell factories to make artificial designer nucleoside drugs and leads via synthetic biology approaches.

2015年7月8日 · In this review, we discuss the recent progress and perspectives on the natural and engineered biosynthesis of nucleoside antibiotics. Natural products play significant roles in mammalian healthcare and plant protection against infections.

2019年9月9日 · To create novel nucleoside antibiotics, strategies used include precursor-directed biosynthesis, mutasynthesis, combinatorial biosynthesis, heterologous expression, and natural product-inspired...