Tryptophan metabolism in health and disease - PubMed
2023年8月8日 · Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function.
Tryptophan - Wikipedia
Metabolism of l -tryptophan into serotonin and melatonin (left) and niacin (right). Transformed functional groups after each chemical reaction are highlighted in red. Amino acids, including tryptophan, are used as building blocks in protein biosynthesis, and proteins are …
Tryptophan Metabolism and Gut-Brain Homeostasis - PMC
Accordingly, dysregulation of tryptophan metabolites plays a central role in the pathogenesis of many neurologic and psychiatric disorders. Gut microbes influence tryptophan metabolism directly and indirectly, with corresponding changes in behavior and cognition.
Tryptophan Metabolism: A Link Between the Gut Microbiota and …
The gut microbial influence on tryptophan metabolism emerges as an important driving force in modulating tryptophan metabolism. Here, we focus on the potential role of tryptophan metabolism in the modulation of brain function by the gut microbiota.
Tryptophan Biochemistry: Structural, Nutritional, Metabolic, and ...
In vertebrates and humans, another main metabolic pathway of Trp is the indole ring breakdown, through the so-called “kynurenine shunt” which produces a number of molecules involved in inflammation, immune response, excitatory neurotransmission, and many other functions.
Tryptophan metabolism in health and disease - ScienceDirect
2023年8月8日 · Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function.
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, …
Tryptophan metabolism, from nutrition to potential therapeutic ...
Apart from its incorporation into body proteins, tryptophan is the precursor for serotonin, an important neuromediator, and for kynurenine, an intermediary metabolite of a complex metabolic pathway ending with niacin, CO (2), and kynurenic and xanthurenic acids.
Tryptophan and its metabolites in normal physiology and cancer ... - PubMed
Within the growing field of amino acid metabolism, tryptophan (Trp) catabolism is an area of increasing interest. Trp is essential for protein synthesis, and its metabolism gives rise to biologically active catabolites including serotonin and numerous metabolites in …
Biochemical and dietary functions of tryptophan and its …
2022年1月1日 · Tryptophan and its metabolites play a pivotal role in growth and development, gut-brain-functions, bone health, immune regulation, mitochondrial functions, and energy metabolism.