Azoles are a class of five-membered heterocyclic compounds containing a nitrogen atom and at least one other non-carbon atom (i.e. nitrogen, sulfur, or oxygen) as part of the ring. [1] Their names originate from the Hantzsch–Widman nomenclature.

Azole antifungal agents can be used to treat fungal infections of the body and skin, including athlete's foot, onychomycosis (fungal nail infections), ringworm, and vaginal candidiasis.

Overview of the pharmacology, mechanism of action, and clinical uses of azole antifungals.

Major developments in research into the azole class of antifungal agents during the 1990s have provided expanded options for the treatment of many opportunistic and endemic fungal infections. Fluconazole and itraconazole have proved to be safer than both amphotericin B …

2024年8月3日 · Note, however, that patients with stable Child's class A-B cirrhosis may be treated with azoles or echinocandins. Induction therapy for patients with dimorphic fungi (although increasing evidence suggests that voriconazole may often be adequate therapy here).

2024年10月17日 · Azole antifungals are key in treating fungal infections, important in both clinical and agricultural settings. They treat a range of pathogenic fungi affecting humans and animals. However, rising resistance highlights the need to understand azoles for effective strategies against fungal pathogens.

2024年3月1日 · The azole family of antifungal agents has indications for many fungal pathogens. They have relatively few adverse effects compared with older agents such as amphotericin B. Due to improved efficacy and safety, the triazole family …

Azoles are a broad class of five-membered heterocycles containing one or more nitrogen atoms with or without other heteroatoms in the ring. Azoles have always been considered as a scaffold of choice in designing of novel therapeutic agents.

Most used antifungal agents are included in the class of azoles. This family of compounds has shown over the decades a vast range of applications in the treatment of fungal infections and diseases, with increasing interest and use in the clinical setting.

1994年1月27日 · For many of the systemic mycoses, the oral azole drugs are effective and safe alternatives to amphotericin B and to the other two older antifungal drugs, flucytosine, an oral fluorinated...