Berberine (BBR), a potential bioactive agent, has remarkable health benefits. A substantial amount of research has been conducted to date to establish the anticancer potential of BBR. The present review consolidates salient information concerning the promising anticancer activity of …

It is concluded that, with further in-depth investigations on their toxicity and efficacy, berberine and its derivatives have the potential for use as drugs in cancer therapy, offering improved clinical efficacy and safety.

2023年6月12日 · Berberine, found in a variety of plants, is used in TCM, Ayurveda, and other medicinal traditions to treat infections, digestive conditions, and inflammatory disorders.

2018年7月27日 · Berberine has been shown in research to work along a number of quite separate pathways against cancer; it reduces blood sugar levels, it reduces inflammation, boosts immune response and attacks certain pathogens; it blocks Akt and mTOR, while promoting AMPK and weakening the cancer cells, and acts as both a chemo-sensitiser and a radio-sensitiser.

2021年12月4日 · BBR prevents cancer cell proliferation by inducing apoptosis and controlling the cell cycle as well as autophagy. BBR also hinders tumor cell invasion and metastasis by down-regulating metastasis-related proteins.

Berberine exhibits an anticancer role through scavenging free radicals, induction of apoptosis, cell cycle arrest, inhibition of angiogenesis, inflammation, PI3K/AKT/mammalian target of rapamycin (mTOR), Wnt/β-catenin, and the MAPK/ERK signaling pathway.

2024年8月10日 · Several studies have evinced that berberine (BBR) is one such natural molecule with potential anticancer and chemosensitizing activities. BBR is an isoquinoline alkaloid, (molecular formula C20H18NO4 and molecular weight 336.3 g/mol) belonging to the structural class of protoberberines with a 5,6-dihydrodibenzo (a,g) quinolizinium skeleton [31].

2020年1月30日 · BBR exerts its anti-inflammation and antioxidant properties, and also regulates tumor microenvironment. This review emphasized that BBR as a potential anti-inflammation and antioxidant agent, also as an effective immunomodulator, is expected to be widely used in clinic for cancer therapy.

2022年7月15日 · In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers.

2022年9月10日 · Berberine exhibits an anticancer role through scavenging free radicals, induction of apoptosis, cell cycle arrest, inhibition of angiogenesis, inflammation, PI3K/AKT/mammalian target of rapamycin (mTOR), Wnt/β-catenin, and the MAPK/ERK signaling pathway.