She was first hired by Guess in the late 1990s. In 2008, she became a spokesmodel for Revlon cosmetics, along with Halle Berry, Jessica Biel, Jennifer Connelly and Jessica Alba, and has also modeled for Double D Ranch and CosmoGirl. She is signed to Vision Model Management, Los Angeles.

Garrett was the female lead in a music video for the song "Cold" by the band Crossfade in 2004, before making her feature film debut in the horror film Turistas (2006), opposite Josh Duhamel, Melissa George, and Olivia Wilde. Prior to appearing in film, Garret had made three appearances on television episodes including a pilot, as well as appearances on Entourage.

In 2007, she was cast in a supporting role as Frankie Raye in Fantastic Four: Rise of the Silver Surfer, the sequel to Fantastic Four. The following year, she had a minor role in the romantic comedy Made of Honor (2008).

In the spring of 2009, she filmed the 2010 film Tron: Legacy in Vancouver, British Columbia, opposite her Turistas co-star Olivia Wilde. In 2010, she also starred in the season-six House episode "Remorse", again with Wilde, as well as the independent crime film Freelancers (2010), starring 50 Cent, Forest Whitaker, and Robert De Niro.

In 2017, Garrett performed the role of attorney Jessica Preston in the hit ABC series The Good Doctor.

In 2024, Garrett was added to the cast of The Madison, an upcoming spinoff series of Yellowstone, set to premiere in 2025.

• Beau Garrett on Twitter
• Beau Garrett at IMDb
• Beau Garrett at Fashion Model Directory