Brivudine (trade names Zostex, Mevir, Brivir, among others) is an antiviral drug used in the treatment of herpes zoster ("shingles"). Like other antivirals, it acts by inhibiting replication of the target virus.

Brivudine, also known by its trade name Brivudin, is an antiviral medication primarily used for the treatment of herpes zoster, commonly known as shingles. Herpes zoster is a painful and often debilitating viral infection caused by the reactivation of the Varicella-Zoster Virus (VZV), the same virus responsible for chickenpox.

2005年6月13日 · Brivudine is a drug used to treat herpes zoster. Generic Name Brivudine DrugBank Accession Number DB03312 Background. Brivudine is used in the treatment of herpes zoster. Although not approved in the U.S. or Canada, it is approved in several European countries. Type Small Molecule Groups Approved, Investigational Structure

Brivudine (BVDU, Zostex™; Figure 1 k) is a 5′-halogenated thymidine nucleoside analogue that exhibits excellent antiviral activity and has been licensed for the treatment of herpes zoster in several European countries.

Brivudine belongs to the class of antiviral drugs called nucleoside analogues, which work by interfering with the replication process of the virus. This article delves into the uses, mechanism of action, side effects, and potential future prospects of Brivudine.

Brivudin is an oral thymidine analogue indicated for the early treatment of acute herpes zoster in immunocompetent adults. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition …

Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir.

Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis.

Background and objective: Brivudine has been used in herpes zoster (HZ) treatment for years, but the safety and efficacy of brivudine are inconclusive. Here we perform a meta-analysis to assess the efficacy, safety, incidence of postherpetic neuralgia of brivudine.

Brivudine is effective in the treatment of HZ, both the short-term (formation of new lesions) and long-term (prevention of PHN) effects, and is as efficient and/or convenient as the other anti-VZV drugs acyclovir, valacyclovir and famciclovir.