ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. [5] [6] This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system.

Flow cytometric assays revealed that CD54+ cells are responsible for antigen uptake, and that expression of CD54 predominantly localizes to APCs. Costimulation, as measured by an allogeneic mixed lymphocytic reaction (alloMLR) assay, showed that activity was restricted to the CD54+ cell population.

Enhanced metastatic ability of TNF-alpha-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotides. Exp Cell Res. 1994;214:231–241. [ DOI ] [ PubMed ] [ Google Scholar ]

CD54, or ICAM-1, is a ligand for the leukocyte integrin complex CD11a/CD18 (LFA-1) and is expressed at differing levels on a variety of cells, including APCs, T cells and B cells [21, 31]. The adhesive interaction between CD54 and LFA-1 facilitates cell–cell contact and is thought to strengthen the immune synapse .

Cluster of Differentiation 54 (CD54), also known as Intercellular Adhesion Molecule 1 (ICAM-1), is a 90 kDa glycosylated transmembrane protein of the immunoglobulin superfamily.

CD54/Intercellular Adhesion Molecule-1 (ICAM-1) is a cell adhesion molecule largely distributed among normal and neoplastic tissues. Through the binding to its ligand(s) CD54 plays a key role in cell to cell interactions leading to the immune response.

2024年12月25日 · ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ICAM1 include Malaria and Cerebral Malaria. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cytokine Signaling in Immune system.

Intercellular adhesion molecule-1 (ICAM-1, CD54) is an inducible cell adhesion glycoprotein of the immunoglobulin supergene family expressed on the surface of a wide variety of cell types.

2008年2月23日 · CD54, or ICAM-1, is a ligand for the leukocyte integrin complex CD11a/CD18 (LFA-1) and is expressed at differing levels on a variety of cells, including APCs, T cells and B cells [21, 31]. The adhesive interaction between CD54 and LFA-1 facilitates cell–cell contact and is thought to strengthen the immune synapse .

2017年4月4日 · Here we describe an unconventional but functional interaction between pro-inflammatory classically activated macrophages (M1MΦ) and MSCs, with CD54 playing a central role. CD54 was upregulated and enriched specifically at the …