Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the tissue in bones [1] and release the minerals, resulting in a transfer of calcium from bone tissue to the blood.

2023年3月17日 · This process of skeletal change is known as bone remodeling, which both protects the structural integrity of the skeletal system and metabolically contributes to the body's balance of calcium and phosphorus.

Calcitriol regulates the levels of calcium and phosphorus in the blood and helps maintain a healthy skeletal system. Bone resorption by osteoclasts releases calcium into the bloodstream, which helps regulate calcium homeostasis.

PTH promotes reabsorption of calcium from the urine by the kidneys, so that the calcium returns to the blood. Finally, PTH stimulates the synthesis of vitamin D, which in turn, stimulates calcium absorption from any digested food in the small intestine.

2023年8月14日 · PTH acts on the kidneys to increase calcium reabsorption in the ascending loop of Henle, the distal convoluted tubule, and the collecting duct. The kidney also responds to PTH by increasing secretion of Vitamin D3, which in turn stimulates calcium absorption through the gut.

2021年6月16日 · maintains normal serum calcium levels by activating osteoclasts for bone resorption and increasing intestinal absorption of calcium (increase serum Ca++)

Bone resorption is the process by which the bones are absorbed and broken down by the body. Osteoclast cells are responsible for the breakdown of bone minerals thus releasing calcium and phosphorous into the bloodstream. This occurs when the …

2016年3月1日 · Here, we reviewed the key mechanisms of calcium homeostasis, including calcium sensing receptor regulation, intestinal calcium absorption, renal calcium reabsorption and bone calcium resorption. We further discussed the roles of dietary calcium and vitamin D in diseases associated with dysfunctional regulation of calcium.

Thus, inflammatory cytokines increase bone resorption in pediatric burn patients, liberating more calcium into the circulation and at the same time upregulating the parathyroid CaSR, effectively lowering circulating calcium.

Besides intestinal absorption and renal reabsorption of calcium, bone resorption is an important mechanism to modulate calcium level in blood. Bone is constantly remodeled by osteoblasts and osteoclast. Osteoblasts facilitate bone formation, while osteoclasts break bone …