Cyclins are generally very different from each other in primary structure, or amino acid sequence. However, all members of the cyclin family are similar in 100 amino acids that make up the cyclin box. Cyclins contain two domains of a similar all-α fold, the first located at the N-terminus and the second at the C-terminus. All cyclins are ...
Cyclin F plays a role in cell cycle regulation through selective ubiquitination or binding of cell cycle proteins. • Cyclin F is involved in DNA synthesis and repair mechanisms, important in the context of genotoxic stress. • Cyclin F dysfunction has been linked to cancer, amyotrophic lateral sclerosis and frontotemporal dementia.