Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. [1] The term is used in the context of resistance that pathogens or cancers have "acquired", that is, resistance has evolved.

The evolutionary pressure of survival drives the emergence of drug resistance, and thereby poses a major challenge to modern medicine. Resistance threatens the longevity of drugs and restricts treatment options for patients, with high prevalence in …

2024年4月22日 · Antimicrobial resistance (AR) happens when germs develop the ability to defeat the drugs designed to kill them. AR has the potential to affect people at any stage of life, as well as the healthcare, veterinary and agriculture industries.

As a result of drug resistance, antibiotics and other antimicrobial medicines become ineffective and infections become difficult or impossible to treat, increasing the risk of disease spread, severe illness, disability and death.

An overview of multiple natural (biological) causes of antimicrobial (drug) resistance from NIAID.

Drug resistance does not involve the host, but is a function of the microbial pathogen present inside the host. As we know that antibiotics are produced by microorganisms and the latter, in order to survive, developed resistance mechanisms to neutralize or destroy their own antibiotics.

2024年5月17日 · AMR occurs when bacteria, viruses, fungi, and parasites no longer respond to medicines, making people sicker and increasing the risk of disease spread, illness and deaths. AMR is driven in large part by the misuse and overuse of antimicrobials.

2025年2月4日 · Antimicrobial resistance (AR) is an urgent global public health threat. In the U.S., more than 2.8 million antimicrobial-resistant infections occur each year. CDC is concerned about the emergence and spread of new forms of resistance and rising resistant infections in the community (outside hospitals).

Antimicrobial resistance is a significant public health problem in the U.S. and around the world as infections are becoming increasingly difficult to treat, especially in healthcare facilities and in people with weakened immune systems.

In this chapter, we discuss the causes and burden of drug resistance and evaluate interventions that address the resistance problem in developing countries.