HIF-1, when stabilized by hypoxic conditions, upregulates several genes to promote survival in low-oxygen conditions. These include glycolysis enzymes, which allow ATP synthesis in an oxygen-independent manner, and vascular endothelial growth …

HIF-1α (Hypoxia-Inducible Factor-1 Alpha) is a critical regulator of cellular responses to hypoxia and plays dual roles in both adaptive survival and pathological injury during stroke. In the event of an ischemic stroke, reduced cerebral blood flow creates a hypoxic environment that stabilizes HIF-1α by preventing its usual proteasomal ...

2025年1月18日 · HIF-1 and HIF-2 are well known and widely described. Although these proteins share a high degree of homology, HIF-1 and HIF-2 have non-redundant roles in cancer. In this review, we summarize the similarities and differences between HIF-1α and HIF-2α in their structure, expression, and DNA binding.

2022年4月21日 · Hypoxia-inducible factors (HIFs) were discovered as activators of erythropoietin gene transcription in response to reduced oxygen (O 2) availability. O 2 -dependent hydroxylation of HIFs on proline and asparagine residues regulates protein stability and …

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a constitutively-expressed HIF-1beta subunit.

Hypoxia-inducible factor (HIF-1) is an oxygen-de-pendent transcriptional activator, which plays cru-cial roles in the angiogenesis of tumors and mam-malian development. HIF-1 consists of a...

2021年2月4日 · Hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor, plays a critical role in adaption to hypoxia, which is a major feature of diseases, including cancer. Protein disulfide isomerase (PDI) is up-regulated in numerous cancers and leads to cancer progression.

2023年3月3日 · We review here these co-regulators and examine their effect on the expression of a compilation of well-characterized HIF-1 direct target genes in order to assess the range of their involvement in the transcriptional response to hypoxia.

6 天之前 · Background Hypoxia is a critical physiological and pathological condition known to influence various cellular processes, including steroidogenesis. While previous studies, including our own, have highlighted the regulatory effects of Hypoxia-Inducible Factor 1α (HIF1α) on steroid production, the specific molecular mechanisms remain poorly understood. This study …

2025年2月12日 · HIF is a heterodimeric transcription factor, and in human cells, the amount of the HIF-1α domain is modulated by enzymes called HIF hydroxylases . The oxygen-dependent degradation domains (ODDs) at the N- and C-termini of HIF-1, Pro 402, and Pro 564 are respectively hydroxylated by the prolyl hydroxylase (PHDs) under normal oxygen circumstances.