2021年6月7日 · Our study demonstrates a small molecule stabilizer of HIF-1α as a promising therapeutic agent for wound healing, and, more importantly, validates the feasibility of treating …

Stabilized HIF1α dimerizes with its constitutively active partner to bind to hypoxia response elements in a coordinate gene cassette that leads to hypoxic adaptation at a cellular, local, …

2023年11月23日 · Roxadustat dosing resulted in significant stabilization of HIF-1α in the retina by 4 weeks, and upregulation in glycolysis-associated proteins (GLUT3, PDK-1) and enzyme …

Here we show that hyperglycemia complexly affects both HIF-1α stability and activation, resulting in suppression of expression of HIF-1 target genes essential for wound healing both in vitro …

2010年10月8日 · It has been reported that reactive oxygen species (ROS), produced under hypoxia by complex III of the mitochondrial electron transport chain, play a critical role in the …

2008年12月9日 · Hypoxia-inducible factor (HIF) 1α is the critical transcription factor that regulates adaptive responses to hypoxia. HIF-1α stability and function is regulated by oxygen-dependent …

HIF-1α stabilizers: Stabilization of HIF-1α can be done with the help of PHD enzyme inhibitors or small molecules that replicate hypoxia. Through this technique, cells repair tissues, while HIF …

2010年10月8日 · It has been reported that reactive oxygen species (ROS), produced under hypoxia by complex III of the mitochondrial electron transport chain, play a critical role in the …

2025年1月6日 · AG1-5 (anti-HIF-1a VHH and hetero-bivalent VHH nanobodies) AG1-5 is a novel anticancer drug that acts as an inhibitor of HIF-1α by binding to HIF-1α and preventing its …

2021年10月1日 · Here, we use a ratiometric, peroxide reporter, HyPer to evaluate the role of peroxide in regulating HIF1α stability. We show that antioxidant enzymes are neither …