Novel HER2 aptamer selectively delivers cytotoxic drug to HER2 …
2012年7月20日 · The Apt-Dox complex could selectively deliver Dox to HER2-positive breast cancer cells while reducing the drug intake by HER2-negative cells in vitro. Moreover, Apt-Dox …
Development of HER2-Specific Aptamer-Drug Conjugate for …
2020年12月21日 · This research suggests the HER2 aptamer-DM1 conjugate as a target-specific anti-cancer modality and provides experimental evidence supporting its enhanced …
Novel HER2 Aptamer Selectively Delivers Cytotoxic Drug to HER2 …
2012年7月20日 · In this paper, we developed a new HER2 aptamer (HB5) by using systematic evolution of ligands by exponential enrichment technology (SELEX) and exploited its role as a …
Aptamer to ErbB-2/HER2 enhances degradation of the target and ... - PubMed
2013年5月14日 · Aptamers, oligonucleotides able to avidly bind cellular targets, are emerging as promising therapeutic agents, analogous to monoclonal antibodies. We selected from a DNA …
Development of a bispecific DNA-aptamer-based lysosome …
2023年3月15日 · In this study, we designed and synthesized HER2-LYTAC based on bispecific DNA, which combines the HER2- and IGFIIR-binding DNA aptamers, and evaluated the effect …
Aptamer to ErbB-2/HER2 enhances degradation of the target and ... - PNAS
2013年2月8日 · This study developed an aptamer with specificity to ErbB-2/human epidermal growth factor receptor 2 (HER2), a master regulator of a signaling network essential for …
Development of HER2-Specific Aptamer-Drug Conjugate for …
In this study, HER2 RNA aptamers were conjugated to mertansine (DM1) and the anti-cancer effectiveness of the conjugate was evaluated in HER2-overexpressing breast cancer models. …
Enhanced aptasensor performance for targeted HER2 breast …
2021年9月21日 · In this research, screen-printed carbon electrodes modified with Au nanoparticle were used to develop an Aptamer based biosensor for HER2 recognition.
Biomimetic Nanoerythrosome‐Coated Aptamer–DNA …
2022年1月22日 · The hybrid erythrosome-based nanoparticles show better inhibition of HER2-positive cancer than other drug formulations and exhibit superior biosafety. With the strengths …
Self-Assembled Multivalent Aptamer Drug Conjugates: Enhanced …
The DNA aptamer-guided drug conjugates (ApDCs) are receiving growing attention for specific tumors due to their excellent tumor affinity and low cost. Therefore, developing a multivalent …