Osteoclasts lie in small cavities called Howship's lacunae, formed from the digestion of the underlying bone. The sealing zone is the attachment of the osteoclast's plasma membrane to the underlying bone. Sealing zones are bounded by belts of …

2023年4月24日 · The lacunae in which osteoclasts are contained, resorbing bone, are known as Howship's lacunae. Lying under the ruffled membrane are numerous visible vacuoles. Some of the vacuoles contain cells visibly undergoing apoptosis.

…on the bone’s surface, called Howship lacunae; the lacunae are thought to be caused by erosion of the bone by the osteoclasts’ enzymes. Osteoclasts are formed by the fusion of many cells derived from circulating monocytes in the blood.

2023年10月30日 · They are found in resorption bays/cavities (a.k.a. Howship lacunae or osteoclastic crypts), which are etched depressions in the bone matrix at sites where bone is being removed. Osteoclats possess a cytoplasm that is rich in mitochondria and vacuoles, the majority of which function as lysosomes.

2023年3月17日 · The differentiated mesenchymal precursors fill the Howship lacunae by depositing new collagen and minerals. Once the osteoblast has completed the task, it will encounter three fates: flatten and become a cell to line the bone surface, become an osteocyte, or undergo cell death (apoptosis).

2023年5月1日 · With a mechanism responsible for building up bone, osteoclasts are the large, multinucleated cells on the surface of bones in pits called Howship lacunae responsible for removing calcium from bone by secreting proteolytic enzymes and hydrogen ions to dissolve the calcium hydroxyapatite crystals.

Howship lacunae - tiny depressions, pits, or irregular grooves in bone that are being resorbed by osteoclasts. Synonym(s): resorption lacunae

2025年1月28日 · The meaning of HOWSHIP'S LACUNA is a groove or cavity usually containing osteoclasts that occurs in bone which is undergoing reabsorption.

Osteoclasts occupy small depressions on the bone’s surface, called Howship lacunae; the lacunae are thought to be caused by erosion of the bone by the osteoclasts’ enzymes. Osteoclasts are formed by the fusion of many cells derived from circulating monocytes in …

Osteoclasts resorb bone in the reverse order from which it was deposited: the inorganic matrix is resorbed first, followed by the organic matrix. The resorption results in shallow depressions in the bone called Howship’s lacunae. Two blood vessels are also present. Spongy woven bone, 400x.