2023年8月28日 · Job Syndrome (Hyper-IgE syndrome) is a rare, primary immunodeficiency distinguished by the clinical triad of atopic dermatitis, recurrent skin staphylococcal infections, and recurrent pulmonary infections. The disease is characterized by elevated IgE levels with an early onset in primary childhood.

Hyperimmunoglobulinemia E syndrome [1] (HIES), of which the autosomal dominant form is called Job's syndrome [1] or Buckley syndrome, [1] is a heterogeneous group of immune disorders. Job's is also very rare at about 300 cases currently in the literature.

Hyper IgE syndromes (HIES) are rare forms of primary immunodeficiencies (PI) characterized by recurrent eczema, skin abscesses, lung infections, eosinophilia (high numbers of eosinophils in the blood), and high serum levels of immunoglobulin E (IgE).

The hyper IgE syndromes (HIES) are rare primary immune deficiencies characterized by elevated serum IgE, rash and recurrent bacterial infections of the skin and lung. Autosomal dominant HIES, the most common disease in this group, results from STAT3 mutations and has a variety of connective tissue and skeletal abnormalities.

Hyper IgE syndrome is an immune deficiency caused by a genetic mutation. It can cause serious skin and lung infections. Read about symptoms, issues and treatment.

Many different syndromes are known to lead to high levels of an antibody called immunoglobulin E, or IgE. Many more such syndromes likely remain unknown. Collectively, these conditions are called hyper-IgE syndromes, or HIES. Other conditions, such as severe eczema, can lead to extremely high IgE levels that are not caused by a syndrome at all.

Hyper IgE syndromes (HIES) are rare primary immune deficiencies characterized by elevated serum IgE, skin inflammation (dermatitis) and recurrent skin and lung infections. Summary.

2023年10月17日 · Hyper-IgE syndrome is a hereditary combined B-cell and T-cell immunodeficiency characterized by recurrent staphylococcal abscesses of the skin, sinopulmonary infections, and severe pruritic eosinophilic dermatitis. Diagnosis is confirmed by measurement of serum IgE levels.

What is Job syndrome? Job syndrome, also called hyper-IgE syndrome, is the name given to a rare inherited immune deficiency characterised by severe infections of the skin and other organs. Job syndrome: eczema

Hyper-IgE syndrome is a hereditary immunodeficiency disorder characterized by recurring skin abscesses, sinus and lung infections, and a severe rash that appear during infancy. Levels of immunoglobulin E (IgE) are very high.