Idoxuridine is an anti- herpesvirus antiviral drug. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing. It is used only topically due to cardiotoxicity.

2005年6月13日 · Idoxuridine is a pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis.

Idoxuridine slows the growth of viruses that cause certain eye infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

2023年2月13日 · Idoxuridine is an iodinated analogue of the nucleosides deoxyuridine and thymidine. It was first synthesized by William H. Prusoff at Yale University (New Haven, CT) in 1958. Five years later, it became the first antiviral drug approved by the US Food and Drug Administration, for topical use against herpes simplex keratitis.

Idoxuridine, which closely resembles thymidine, inhibits thymidylic phosphorylase and specific DNA polymerases, which are necessary for the incorporation of thymidine into viral DNA. Idoxuridine is incorporated in place of thymidine into viral DNA, resulting in faulty DNA and the inability to infect or destroy tissue or to reproduce ...

Idoxuridine is an iodinated thymidine derivative with activity against HSV. Use of idoxuridine has been limited to topical application, since systemic administration is associated with significant myelosuppression.

Idoxuridine is a halogenated pyrimidine nucleoside that resembles thymidine. An antiviral agent, idoxuridine is used primarily for the treatment of herpetic keratitis. It displays a significant, nonselective cytotoxicity in addition to antiviral activity when administered systemically.

Idoxuridine (IDU) and trifluridine (TFT) are the first drugs from which the era of antiviral drug therapy began. In 1959, Prusoff 3a described iodo-deoxyuridine synthesized by many viruses as a potential anticancer agent.

2013年11月8日 · Idoxuridine is used to treat eye infections caused by viruses. This medication is no longer available in the United States. Pharmacist Stephen Lozano, PharmD summarizes the uses, common side effects, and warnings for the antivirals class of medications.

An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is incorporated into …