Immune checkpoint inhibitors are a type of immunotherapy that block immune checkpoint proteins from binding with partner proteins. Learn about the cancers treated with checkpoint inhibitors and the side effects they may cause.

2016年1月22日 · However, those tumor- destroying immune cells are often held back by a series of molecules known as immune check- points." Normally, Drake explains, these checkpoints function to protect the body from auto-immune attack; "but in cancer, tumors hijack those pathways to protect themselves, instead."

2020年5月28日 · Immune checkpoint blockade therapy has become a major weapon in fighting cancer. Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious advantages such as broad applicability...

Immune checkpoint inhibitors, like PD-1 or PD-L1 inhibitors, are treatments that help the immune system recognize and attack cancer cells. Learn more here.

2024年1月4日 · Immune checkpoints are a type of immunosuppressive molecules expressed on immune cells, which can regulate the degree of immune activation and avoid autoimmune responses. ICIs, such...

Immune checkpoints are the regulatory checkpoints of immune cells that play a crucial role in self-tolerance by inhibitory pathways to minimize the collateral tissue damages from own immune cells by maintaining immune homeostasis and hence prevent the auto-immunity in the body.

In this review, we discuss immune checkpoint signaling in the different immune cells with their biological consequences and summarize new immune checkpoint therapies that are under investigation in clinical trials or in development to bypass resistances and to improve the outcome of these therapies.

Immune checkpoint inhibitors (ICIs), block these interactions, and when administered not only as monotherapy but also as part of combination regimens, have shown to improve survival results in multiple advanced cancers leading to an increasing number of patients treated with ICI and, as a consequence, a rise in the number of patients developing ...

A number of immunological checkpoints control cells of the innate and adaptive immune system that determine their function. Stimulatory checkpoint pathways promote activation of naïve T cells, as well as effector, memory and regulatory T cell responses.

2023年4月13日 · Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer patients and conferred durable clinical benefits, including cure in a subset of patients.