2014年2月1日 · Insulin is stored as microcrystalline arrays of zinc insulin hexamers within specialized glucose-regulated secretory vescicles. Regulation of insulin secretion is coupled to metabolism and electrophysiologic events involving plasma membrane depolarization and calcium-ion homeostasis.

2025年2月3日 · Insulin is a protein composed of two chains, an A chain (with 21 amino acids) and a B chain (with 30 amino acids), which are linked together by sulfur atoms. Insulin is derived from a 74-amino-acid prohormone molecule called proinsulin. Proinsulin is relatively inactive, and under normal conditions only a small amount of it is secreted.

The human insulin protein is composed of 51 amino acids, and has a molecular mass of 5808 Da. It is a heterodimer of an A-chain and a B-chain, which are linked together by disulfide bonds. Insulin's structure varies slightly between species of animals.

Insulin is a small globular protein containing two chains, A (21 residues) and B (30 residues) (Fig. 2.1A). Stored in the β cell as a Zn 2+ -stabilized hexamer, the hormone dissociates in the bloodstream to function as a Zn 2+ -free monomer (Fig. 2.1B).

In summary, insulin's three-dimensional structure is that of a compact globular protein but one that has to fulfill many functions—storage in the pancreatic β cells, transport in the plasma, receptor engagement and, ultimately, to be available for proteolytic degradation within the endosome.

Insulin Receptor. Structure. Heterotetrameric glycoprotein (two α- and two β-subunits, joined by disulfide bonds). α-subunits: extracellular, bind insulin. β-subunits: transmembrane + intracellular, have intrinsic tyrosine kinase activity. Signal Transduction. Insulin binding → autophosphorylation of β-subunit tyrosine residues.

2024年2月8日 · Insulin is a peptide hormone produced by beta cells within the pancreas. It is responsible for regulating the movement of glucose from the blood into cells. It is released in an endocrine fashion into the bloodstream.

2008年8月19日 · Structure of human insulin. PDB DOI: https://doi.org/10.2210/pdb3E7Y/pdb; Classification: HORMONE; Organism(s): Homo sapiens; Expression System: Escherichia coli; Mutation(s): No ; Deposited: 2008-08-19 Released: 2009-02-24 ; Deposition Author(s): Timofeev, V.I., Baidus, A.N., Kislitsyn, Y.A., Kuranova, I.P.

The hormone insulin is a protein consisting of 2 polypeptide chains. In the beta cells within islets of Langerhans of the pancreas, insulin is originally produced as a single molecule (preproinsulin) composed of 110 amino acids.

Know comprehensive Insulin protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.