2025年1月3日 · Ivermectin is extensively metabolized in the liver and should be used cautiously in patients with hepatic disease. Dosage adjustments may be needed, although specific recommendations are not currently available. The manufacturer does not recommend that ivermectin treatment be excluded in patients with liver disease.

2024年1月15日 · Ivermectin is well tolerated compared to other microfilaricidal agents (i.e., thiabendazole, diethylcarbamazine). Adverse reactions (i.e., pruritus , fever, rash, myalgia, headache) occur commonly during the first 3 days after treatment and appear to be related to the extent of parasitic infection and systemic mobilization and killing of ...

2025年2月4日 · Administration of 30 mg ivermectin following a high-fat meal resulted in an approximate 2.5-fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state. In vitro studies using human liver microsomes and recombinant CYP450 enzymes have shown that ivermectin is primarily metabolized by CYP3A4.

2020年4月10日 · Although further study is needed, some data obtained from individuals in Ghana who received ivermectin in mass treatment programs of onchocerciasis (communities had received 6–18 rounds of treatment) suggest that ivermectin resistance in O. volvulus may be developing in some communities and is manifested as a more rapid return to high ...

2024年7月19日 · Ivermectin tablets are an FDA approved medicine for treatment of intestinal worms Strongyloides stercoralis and Onchocerca volvulus. Ivermectin cream 1% (Soolantra) is FDA approved for treatment of rosacea. Ivermectin is not FDA approved to treat COVID-19. Ivermectin tablets are also used off-label for a number of other conditions.

Ivermectin User Reviews & Ratings. Brand names: Stromectol Ivermectin has an average rating of 7.7 out of 10 from a total of 29 reviews on Drugs.com. 67% of reviewers reported a positive experience, while 15% reported a negative experience.

Ivermectin Interactions There are 101 drugs known to interact with ivermectin , along with 1 alcohol/food interaction. Of the total drug interactions, 1 is major, 98 are moderate, and 2 are minor.

2024年11月5日 · The recommended dosage of STROMECTOL for the treatment of strongyloidiasis is a single oral dose designed to provide approximately 200 mcg of ivermectin per kg of body weight. See Table 1 for dosage guidelines. Patients should take tablets on an empty stomach with water. (See CLINICAL PHARMACOLOGY, Pharmacokinetics.) In general, …

2025年1月3日 · Ivermectin has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of teratogenicity, but at doses that were also maternotoxic to the pregnant female. The manufacturer considers ivermectin contraindicated during pregnancy. Two cases of the use of ivermectin during pregnancy have been reported.

Ivermectin is not known to cause infertility, and it is not stated as a side effect on the FDA label. In September 2021, misinformation was spread online about ivermectin causing male infertility. It was based on a very small flawed 2002 study mentioned in a 2011 study.