2023年10月26日 · Compared to APP/PS1 or P301S APOE3 mice, those expressing APOE4, be it full-body or just in their microglia, had more homeostatic cells and fewer DAMs/MGnDs. ApoE4 microglia upregulated homeostatic drivers, including TGFβ and PU.1. Genetic variants near PU.1 reportedly increase its expression and delay AD onset, potentially by suppressing ...

2024年6月29日 · Interestingly, ablation of either CD8+ T cells or microglia alleviates the myelin deficit and improves behavioral outcomes, suggesting that both cell types are implicated in the white matter pathology. It is known that CD8+ T cells and microglia interact with each other in the context of AD (Chen et al., 2023). However, the key question is ...

2023年9月1日 · Based on findings from the PiChip system, scientists propose that in the AD brain, neurons churning out Aβ incite astrocytes to summon peripheral T cells via CXCL10. Microglia also become activated. Once T cells arrive, the two together set off a pro-inflammatory cascade that kills neurons. [Courtesy of Jorfi et al., Nature Neuroscience, 2023.]

2015年6月5日 · Moreover, 173 genes that normally taper off in mature microglia were upregulated, including those important for transcriptional regulation, survival, and proliferation. Surface molecules typical of immature microglia also dotted their cell membranes. Together, the results suggest microglia in germ-free mice were stalled in a juvenile state.

2023年3月22日 · T Cells in the Brain. This video shows that in a mouse model of tauopathy, T cells (green) cozy up to microglia (red) in brain tissue rather than endothelial cells (turquoise), confirming that the T cells are truly in the parenchyma, and not in the blood vessels. [Courtesy of Chen et al., Nature 2023.]

2017年8月30日 · What is special for microglia cells is that they seed the CNS very early during embryonic development and probably very little after birth. In other words, most evidence so far, almost all from studies with mice, show that these cells are maintained in the CNS through adulthood, but do not need a constant feed from the bone marrow, unlike other ...

Because microglia are a diverse lot and make up only a small fraction of cells in the brain, Taga and colleagues developed an automated technique to scan an entire brain section at high resolution, pick out all of the microglia based on their expression of Iba1, and then study other features of the cells (De Jager et al., 2024). In Lisbon, Taga ...

2020年12月11日 · The paper by Olah et al. evaluates the microglial signature through scRNA-seq analyses of live microglia cells from 10 Alzheimer’s disease (AD), four mild cognitive impairment (MCI) and three temporal lobe epilepsy (TLE) patients and compares these data with microglial signatures from two mouse models of neurodegeneration (CKp25 and 5XFAD ...

2024年6月8日 · Iyer found that microglia from all donors expressed tau, though at levels much lower than what is seen in neurons. Tau Tempers TREM2. Wild type, induced microglia-like cells (left) produce much more TREM2 (cyan) than iMGLs expressing the IVS10+16 tau mutation (right). The latter have much less TREM2 on the cell surface (not shown).

2019年5月23日 · Myriad studies have placed microglia right in the middle of AD pathogenesis, but defining what, when, and how these cells influence the disease process in a person’s brain is difficult. Three recent gene-expression studies—one in Nature and two posted on bioRχiv—took the plunge into postmortem brain samples to try to find out how ...