很多 研究证明 miRNA是通过参与调节其下游基因翻译过程面发挥其生物学功能。 比如，Lai等观察到果蝇miR-2a、miR-2b、miR-6、miR-11、miR-13a及miR-13b等的5'端6~8nt序列具有一定的 …

2012年6月5日 · This Review describes recent advances, with an emphasis on how the miRNA-mediated silencing complex (miRISC) controls gene expression by inhibiting translation and/or …

MicroRNA (miRNA)-induced silencing complexes (miRISCs) repress translation and promote degradation of miRNA targets. Target degradation occurs through the 5'-to-3' messenger RNA …

2023年3月24日 · miRNA 是一种内源性的微小非编码 RNA，长度一般在 21-23 个核苷酸之间，具有在翻译水平调控基因表达的功能[2]。 miRNA 的发生 “成长” 需要几个步骤：最初，miRNA …

To exert their regulatory function, miRNAs associate with Argonaute proteins to form the core of the miRNA-induced silencing complex (miRISC). miRISC is a multi-protein assembly that uses …

2018年5月3日 · miRISC is a multi-protein assembly that uses microRNAs (miRNAs) to identify mRNAs targeted for repression. Dozens of miRISC-associated proteins have been identified, …

The miRISC functions to identify the target transcripts first and then silence the gene expression of the target mRNA. The miRISC uses imperfect base complementarity to identify the target …

2018年5月3日 · miRISC is a multi-protein assembly that uses microRNAs (miRNAs) to identify mRNAs targeted for repression. Dozens of miRISC-associated proteins have been identified, …

2018年10月22日 · Following a series of regulated endonucleolytic processing events, mature miRNAs are generated and loaded into the Argonaute effector proteins that form the core of …

The miRISC function has two primary components, target recognition and silencing of the targeted transcript. The miRNA-element confers specificity to the target, while the gene expression …