Most E. coli strains are harmless, but pathogenic varieties cause serious food poisoning, septic shock, meningitis, or urinary tract infections in humans. [ 1 ] [ 2 ] Unlike normal flora E. coli , the pathogenic varieties produce toxins and other virulence factors that enable them to reside in parts of the body normally not inhabited by E. coli ...

By one means or another, pathogenic E. coli have evolved several mechanisms by which they can damage host cells and cause disease. Pathotypes and pathogenesis. Enteropathogenic E. coli (EPEC).

2024年10月26日 · E.coli strains produce four types of toxins that have a cytotoxic effect on the host cells. Stable toxin (ST)- Small Peptides activate membrane-bound guanylate cyclase. A diverse number of E.Coli are present in gastrointestinal microflora …

2023年7月13日 · Pathogenic strains cause intestinal illness in humans when ingested. Escherichia coli results in intestinal illness as well as infection outside of the intestine. Intestinal illness caused by E. coli is caused by one of five subtypes, and they are identified according to their O and H antigens.

Enteric E. coli pathotypes are implicated in many diseases through distinctly different pathogenesis. Pathogenesis is the process by which pathogens cause disease or disorder, often by expressing virulence-factor-encoding genes [7, 8].

The following diagrams show how pathogenic E. coli of each pathotype cause disease. Follow the appropriate links to learn which virulence factors are involved in each step of the disease process, and what are the important O serotypes and virotypes.

Some strains of E. coli have evolved into pathogenic E. coli by acquiring virulence factors through plasmids, transposons, bacteriophages, and/or pathogenicity islands. Pathogenic intestinal E. coli may be classified into four strains based on the diarrhea-causing mechanism.

2024年5月14日 · Pathogenic E. coli are categorized into pathotypes based on their virulence genes. The six pathotypes of diarrheagenic E. coli are: (Pathotypes that cause urinary tract infections, bloodstream infections, and meningitis are not covered here.)