Peptide nucleic acid (PNA) is an artificially synthesized polymer similar to DNA or RNA. [1] Synthetic peptide nucleic acid oligomers have been used in recent years in molecular biology procedures, diagnostic assays, and antisense therapies. [2] .

Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs, which were first synthesized in 1991 by Peter E. Nielsen and colleagues. As shown in figure 1, unlike DNA and RNA, the phosphate sugar backbone of PNA is replaced by repeating N- (2-aminoethyl)-glycine units.

2020年9月29日 · Peptide Nucleic Acid (PNA) serves as an artificial functional analog of DNA. Being immune to enzymatic degradation and possessing strong affinity towards DNA and RNA, it is an ideal candidate for many medical and biotechnological applications that are of antisense and antigene in nature.

1999年1月4日 · Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range of important applications. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands.

Peptide nucleic acids (PNAs) are synthetic mimics of DNA in which the deoxyribose phosphate backbone is replaced by a pseudo-peptide polymer to which the nucleobases are linked. PNAs...

2004年5月19日 · Peptide nucleic acids (PNAs) are synthetic DNA mimics in which the sugar phosphate backbone is replaced by repeating N-(2-aminoethyl) glycine units linked by an amine bond and to which the nucleobases are fixed.

PNA (Peptide Nucleic Acid) is an artificially synthesized polymer similar to DNA or RNA. The various purine and pyrimidine bases are linked to the backbone by methylene carbonyl bonds as in peptides.

Peptide nucleic acids (PNAs) combine the programmability of native nucleic acids with the robustness and ease of synthesis of a peptide backbone. These designer biomolecules have demonstrated tremendous utility across a broad range of applications, from the formation of bespoke biosupramolecular architectures to biosensing and gene regulation.

Peptide nucleic acid (PNA) is an artificial DNA analog in which the negatively charged phosphodiester backbone is replaced by a charge-neutral pseudopeptide backbone. PNA exhibits several conformational flexibilities.

2023年1月17日 · DNA-like molecules, peptide nucleic acids (PNAs), that bind even more strongly to nucleic acids and are not broken down in the body by enzymes that target DNA or RNA. These qualities could make them potent therapeutics aimed at silencing or editing genes. PNAs are long molecular strands of nucleobases, much like DNA. But unlike DNA, their backbones