Protein kinase A - Wikipedia
Protein kinase A, more precisely known as adenosine 3',5'-monophosphate (cyclic AMP)-dependent protein kinase, abbreviated to PKA, was discovered by chemists Edmond H. Fischer and Edwin G. Krebs in 1968.
Protein Kinase A in neurological disorders | Journal of ...
2024年3月13日 · Cyclic adenosine 3’, 5’ monophosphate (cAMP)-dependent Protein Kinase A (PKA) is a multi-functional serine/threonine kinase that regulates a wide variety of physiological processes including gene transcription, metabolism, and synaptic plasticity.
Protein Kinase A - Colorado State University
Like other protein kinases, protein kinase A (also known as the cyclic AMP-dependent protein kinase or A kinase) is an enzyme that covalently decorates proteins with phosphate groups. The unique characteristic of protein kinase A is that its activity is regulated by fluctuating levels of cyclic AMP within cells (hence its alias as the cyclic ...
Protein kinase - Wikipedia
A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules.
Molecule of the Month: cAMP-dependent Protein Kinase (PKA)
Protein kinases are used to add phosphate groups to proteins. The one shown here is cAMP-dependent protein kinase, also known as protein kinase A or PKA (PDB entries 3tnp , 1j3h and 2h9r ). It is composed of two types of subunits.
Protein Kinase A: The Enzyme and Cyclic AMP Signaling
2010年1月1日 · Cyclic AMP signaling starts after a ligand stimulates a G-protein coupled receptor (GPCR); the final steps are completed by phosphorylation of a number of substrate proteins by its serine-threonine protein kinase (PKA) mediator.
Protein Kinase A (PKA)
One particular example of a protein kinase found inside our body is protein kinase A (PKA). PKA is activated when the sympathetic nervous system kicks in and initiates the flight-or-fight response during stressful, dangerous or exciting situations.
Physiological and pathological roles of protein kinase A in the heart
2021年1月23日 · Protein kinase A (PKA) is a central regulator of cardiac performance and morphology. Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress signals, most notably catecholamines secreted by the sympathetic nervous system.
Protein kinases have essential activities in almost all areas of cell biology and physiology, making their dysfunctions commonly linked to illnesses. The protein kinase A (PKA), also 5' -cyclic adenosine monophosphate (cAMP) dependent protein kinase, was
Crystal Structures Reveal Hidden Domain Mechanics in Protein Kinase A …
2023年10月26日 · Cyclic-AMP-dependent protein kinase A (PKA) is a critical enzyme involved in various signaling pathways that plays a crucial role in regulating cellular processes including metabolism, gene transcription, cell proliferation, and differentiation.