SH-SY5Y is a human derived cell line used in scientific research. The original cell line, called SK-N-SH, from which it was subcloned was isolated from a bone marrow biopsy taken from a four-year-old female with neuroblastoma. SH-SY5Y cells are often used as in …

The SH-SY5Y cell line is a thrice cloned subline of the neuroblastoma cell line SK-N-SH (ATCC HTB-11), which was established in 1970 from a metastatic bone tumor from a 4-year-old cancer patient. Applications include use as a transfection host or in immunology, neuroscience, and toxicology research.

2023年1月18日 · 人神经母细胞瘤细胞（SH-SY5Y） 是于1970年建自骨瘤转移灶的神经母细胞瘤 SK-N-SH细胞系经3次克隆后的亚系(SK-N-SH→SH-SY→SH-SY5→SH-SY5Y)。该细胞的密度可高达106 cells/cm2，具有中等水平的 多巴胺β羟化酶 的活性。基本形态上皮样，多数贴壁，少数悬 …

三次克隆后的亚系(sk-n-sh→sh-sy→sh-sy5→sh-sy5y)。 据报道SH-SY5Y 细胞的饱和密度大于1×10 6 细胞/cm 2 ，细胞表达中等的多巴胺β羟化酶活性。

SH-SY5Y is a thrice-subcloned cell line derived from the SK-N-SH neuroblastoma cell line. It serves as a model for neurodegenerative disorders since the cells can be converted to various types of functional neurons by the addition of specific compounds.

2023年6月17日 · sk-n-sh细胞的成神经细胞样亚克隆被命名为sh-sy细胞，后来被亚克隆为sh-sy5细胞，接着再进行第三次亚克隆以产生sh-sy5y细胞，最早于1978年报导 [1] 。 形态学

SH-SY5Y cells differentiate primarily to a cholinergic neuron phenotype in response to RA treatment, as evidenced by increased expression of choline acetyl transferase (ChAT) activity and vesicular monamine transporter (VMAT) expression [7, 15].

The SH-SY5Y human neuroblastoma cell line (ATCC® CRL-2266™) is one of the most used cell lines in neurosciences, either undifferentiated or differentiated into neuron-like cells.

The immortalized and proliferative cell line SH-SY5Y is one of the most commonly used cell lines in neuroscience and neuroblastoma research. However, undifferentiated SH-SY5Y cells share few properties with mature neurons. In this study, we present ...

SH-SY5Y cells are phenotypically adrenergic and express dopaminergic markers, making them a useful in vitro model for studying neurodegenerative diseases, neurogenesis, and brain cell characteristics [1]. SH-SY5Y cells grow as clumps of viable neuroblastic cells with neurites and are loosely adherent. The cell size of SH-SY5Y cells is 12 μm.