2005年2月28日 · Eukaryotes produce various types of small RNAs of 19-28 nt in length. With rapidly increasing numbers of small RNAs listed in recent years, we have come to realize how widespread their functions are and how diverse the biogenesis pathways have evolved.

2022年4月12日 · The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs derived from longer...

2025年1月15日 · Small RNAs are a type of non-coding RNA (ncRNA) molecule that are 50 250 nucleotides in length. They are often involved in regulating the translation of target RNAs through RNA RNA...

2008年4月21日 · A small number of microRNAs are expressed mainly in embryonic stem (ES) cells, and attention has naturally focused on their roles in maintaining the pleuripotent undifferentiated state, self ...

2005年9月2日 · Small RNA guides—microRNAs, small interfering RNAs, and repeat-associated small interfering RNAs, 21 to 30 nucleotides in length—shape diverse cellular pathways, from chromosome architecture to stem cell maintenance.

2024年4月11日 · Small RNA-seq enables the comprehensive characterization of small RNA expression profiles in different tissues, developmental stages, and disease conditions. By quantifying the abundance of small RNAs, researchers can identify tissue-specific or disease-associated small RNAs.

2024年11月14日 · While small RNA pathways have been well documented with clearly defined mechanisms, lncRNAs exhibit a greater diversity of mechanisms, many of which remain unknown. This Review covers pivotal events in their discovery, biogenesis pathways, evolutionary traits, action mechanisms, functions, and crosstalks among ncRNAs.

Small non-coding RNAs (sncRNAs), such as microRNAs (miRNAs), small interfering RNAs (siRNAs), PIWI-interacting RNAs (piRNAs), and transfer RNA (tRNA)-derived small RNAs (tsRNAs), play essential roles in regulating various cellular and developmental processes.

2005年2月1日 · Two relatively well-defined classes of small RNAs are involved in RNA silencing: microRNAs (miRNAs) and small interfering RNAs (siRNAs) (Table 1, shaded in yellow). MiRNA is often pronounced in full ( ma-i-kro-RNA ), while siRNA is …

2024年10月10日 · In recent years, the understanding of small RNA molecules has expanded significantly, revealing their role in gene regulation. These tiny entities are not just passive players but active regulators that influence various biological processes by modulating gene expression.