How telomeres contribute to aging and age-related diseases came to light through the study of mice and individuals harboring germline alterations in telomere maintenance genes. Murine and human telomeres show differences in length and regulation.

2023年2月20日 · Telomeres play a role in how fast cells age, though exactly how isn't totally clear. Organisms without circular chromosomes — including humans, other animals, plants and even...

2024年8月8日 · Shorter telomeres have been associated with increased disease incidence and decreased survival times. Senescent cells no longer divide, but remain active and have been implicated in many diseases...

2022年2月14日 · Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere...

The crucial role of telomeres in cell turnover and aging is highlighted by patients with 50% of normal telomerase levels resulting from a mutation in one of the telomerase genes. Short telomeres in such patients are implicated in a variety of disorders including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis, and cancer.

Recent studies indicate that telomere length, which can be affected by various lifestyle factors, can affect the pace of aging and onset of age-associated diseases. Telomere length shortens with age.

Telomeres are at the non-coding ends of linear chromosomes. Through a complex 3-dimensional structure, they protect the coding DNA and ensure appropriate separation of chromosomes. Aging is characterized by a progressive shortening of telomeres, which …

2021年1月21日 · The intimate link of telomeres to aging hallmarks informs preventive and therapeutic interventions designed to attenuate aging itself and reduce the incidence of age-associated diseases.

2021年1月14日 · How telomeres contribute to aging and age-related diseases came to light through the study of mice and individuals harboring germline alterations in telomere maintenance genes. Murine and human telomeres show differences in length and regulation.

Telomere dysfunction during cellular aging (a state in which cells do not divide but are metabolically active) affects the health of the body. [2] Preventing telomere shortening without clearing old cells may lead to the accumulation of these cells in the body and contribute to age-related diseases and tissue dysfunction.