2016年9月12日 · The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review...

The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and …

We summarize the latest advances on the intrinsic and extrinsic regulation of Wnt signaling and describe a model in which incremental levels of pathway activities shape a hierarchical organization of both normal and cancerous tissues.

2022年1月3日 · Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin...

2020年2月10日 · In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt...

The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response. Accumulated investigations highlight the therapeutic ...

2024年6月18日 · With increasing evidence supporting the involvement of the Wnt/β-catenin pathway in carcinogenesis, researchers envision its potential to pave the way for targeted drug development in cancer treatment.

Here, we review the mechanisms whereby WNT signaling impinges on immune functions, with a special emphasis on cancer immunosurveillance, and discuss the therapeutic potential of harnessing currently available WNT modulators to implement cancer immunotherapy.

In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects such as impairment of tissue homeostasis and regeneration.

The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and …