Organoids, embryoids and gastruloids provide a new platform for the study of mechanisms that underlie size and timing control in development, and the rapid advances in generating, characterizing and quantitatively analyzing these structures are likely to lead to many discoveries in the near future.

2021年1月27日 · In this Focus issue, we highlight studies that demonstrate the promise of organoids and embryoids. In their Article, Eileen Gentleman, Joana Neves and colleagues investigated the role of a rare...

2021年8月26日 · The difficulty of studying post-implantation development in mammals has sparked a flurry of activity to develop in vitro models, termed embryoids, based on self-organizing pluripotent stem cells.

In recent years, it has been shown that three-dimensional cultures of stem cells can spontaneously form complex biological structures that resemble organs (organoids) and embryos (embryoids). These discoveries have prompted a renaissance of the concept of self-organization.

2017年3月15日 · Here, we examine how such approaches are being used to answer fundamental questions in embryology, such as how cells self-organize and assemble, how the embryo breaks symmetry, and what controls timing and size in development.

2023年5月30日 · We review recently developed strategies of making 3D models of the human embryo built from embryonic stem cells, which we refer to as embryoids. We focus on models aimed at reconstituting the 3D epithelial characteristics of the early human embryo, namely the intra/extraembryonic signaling crosstalk, tissue polarity, and embryonic cavities.

While research on stem cell-derived tissues and organoids is rapidly expanding, the technically related creation of complex embryoids has recently excited a vivid discussion since it raises ethical questions about individuation and the possible gain of viability.

Embryoids are distinct from organoids, as organoids are organized multicellular structures that mimic the development, regeneration and homeostasis of a single tissue or organ. In contrast, embryoids aim to model integrated development of the …

2022年8月25日 · Our results demonstrate the self-organization ability of ES cells and two types of extraembryonic stem cells to reconstitute mammalian development through and beyond gastrulation to neurulation...

2023年5月30日 · We review recently developed strategies of making 3D models of the human embryo built from embryonic stem cells, which we refer to as embryoids. We focus on models aimed at reconstituting the 3D epithelial characteristics of the early human embryo, namely the intra/extraembryonic signaling crosstalk, tissue polarity, and embryonic cavities.