2006年6月1日 · Protein traffic moving from the endoplasmic reticulum (ER) to the Golgi complex in mammalian cells passes through the tubulovesicular membrane clusters of the ER-Golgi intermediate compartment (ERGIC), the marker of which is the lectin ERGIC-53.

2006年6月1日 · Protein traffic moving from the endoplasmic reticulum (ER) to the Golgi complex in mammalian cells passes through the tubulovesicular membrane clusters of the ER-Golgi intermediate compartment (ERGIC), the marker of which is the lectin ERGIC-53. The dynamic nature and functional role of the ERGIC have been debated for quite some time.

We developed a systematic membrane isolation scheme to identify the endoplasmic reticulum–Golgi intermediate compartment (ERGIC) as a primary membrane source both necessary and sufficient to trigger LC3 lipidation in vitro.

2024年3月16日 · ERGIC-53 transports certain subsets of newly synthesized secretory proteins and membrane proteins from the endoplasmic reticulum to the Golgi apparatus.

2013年8月6日 · We developed a systematic membrane isolation scheme to identify the endoplasmic reticulum–Golgi intermediate compartment (ERGIC) as a primary membrane source both necessary and sufficient to trigger LC3 lipidation in vitro. Functional studies demonstrate that the ERGIC is required for autophagosome biogenesis in vivo.

2020年6月10日 · The ERGIC is a tubulo-vesicular compartment closely associated with the ER-exit sites (ERES). Interestingly, the Malhotra lab identified a special compartment, called the compartment for unconventional protein secretion (CUPS), which regulates UCPS of …

2000年2月15日 · Beyond its interest as a transport receptor, ERGIC-53 is an attractive probe for studying numerous aspects of protein trafficking in the secretory pathway, including traffic routes, mechanisms of anterograde and retrograde traffic, retention …

2004年11月5日 · We propose that ERGIC-32 functions as a modulator of the hErv41-hErv46 complex by stabilizing hErv46. Our novel approach for the isolation of the ERGIC from BFA-treated cells may ultimately lead to the identification of all proteins rapidly cycling early in the secretory pathway.

2021年9月24日 · Here we identify a new type of membrane contact formed between the ER–Golgi intermediate compartment (ERGIC) and the ER-exit site (ERES) in the ER–Golgi system, which is essential for...

2013年5月23日 · The ERGIC as a distinct intermediate organelle Implicit in the ER–Golgi organization of eukaryotic species are different strategies to efficiently transport cargo from the ER to the Golgi.

ERGIC-53 is a type I transmembrane protein. It includes an N-terminal signal sequence, a carbohydrate recognition domain, which is calcium-dependent and pH-sensitive, a stalk region, a transmembrane domain, and a short cytoplasmic domain; ERGIC-53 mainly acts as a receptor of a limited number of gly …

2022年2月28日 · Yan et al. unveil an unconventional, highly elongated tubular ERGIC (t-ERGIC), which selectively accelerates the ER-to-Golgi trafficking of soluble cargoes of the receptor SURF4, suggesting that the diversity of ER-to-Golgi transport carriers is attributable to distinct cargo-receptor interactions.

Initially ERGIC was thought as an intermediate station for vesicle transport between the endoplasmic reticulum (ER) and the Golgi by regulating cargo sorting and bidirectional traffic in the early secretory pathway. Recently, ERGIC has been found to play essential roles in regulating several key cellular processes under stress conditions.

2024年3月19日 · In mammalian cells, the ER-derived cargoes are carried by tubular-vesicular membrane clusters, termed the ER-Golgi intermediate compartment (ERGIC), to achieve long-distance cargo transport from the ER exit sites (ERES), distributed at the cell periphery, to the Golgi ribbon, a huge structure composed of interconnected Golgi stacks located near ...

2023年1月1日 · Here, we briefly summarize the role of ERGIC in autophagy and discuss how ERGIC-associated membranes are committed to autophagosome formation in response to starvation or other stresses. The ERGIC was first identified as the intermediate compartment in ER-to-Golgi transport of the viral proteins.

2024年6月26日 · This study highlights the pivotal role of ERGIC-localized Rabs in governing cargo translocation and specifying the ERGIC’s function in UcPS.

The meaning of -ERGIC is exhibiting or stimulating activity of. How to use -ergic in a sentence.

2017年9月25日 · Silencing lncRNAL20992 revealed its significant functions involved in promoting cell apoptosis and inhibiting cell proliferation according to cell-counting kit-8, EdU assay, terminal deoxynucleotidyl transferase dUTP nick-end labeling, and western blot.

2019年2月1日 · Results: This systematic review and meta-analysis will provide high-quality evidence from several aspects, including for efficacy, blood pressure, blood lipid and adverse effects to evaluate the...