Macrolides mainly affect gram-positive cocci and intracellular pathogens such as mycoplasma, chlamydia, and legionella. Erythromycin was the first macrolide discovered; other macrolides include azithromycin, clarithromycin, and roxithromycin.

What Are Names of Macrolide Drugs? What Are Macrolides and How Do They Work? Macrolides are antibiotics used for infections caused by gram -positive bacteria (streptococcal and pneumococcal infections).

The first macrolide discovered was erythromycin, which was first used in 1952. Erythromycin was widely used as a substitute to penicillin in cases where patients were allergic to penicillin or had penicillin-resistant illnesses.

2020年2月1日 · Review the appropriate monitoring necessary for patients on agents in the macrolide class of antibiotics. Describe interprofessional team strategies for improving the proper administration and management of macrolide antibiotics.

Macrolide antibiotics inhibit protein synthesis by targeting the bacterial ribosome. They bind at the nascent peptide exit tunnel and partially occlude it. Thus, macrolides have been viewed as ‘tunnel plugs’ that stop synthesis of every protein.

Because macrolides are active against atypical respiratory pathogens, they are often used empirically for lower respiratory tract infections, but another antibiotic is often necessary to cover macrolide-resistant pneumococci.

With the macrolide clarithromycin, harmful effects on the fetus have been observed in animal studies. Therefore, pregnant women should not take clarithromycin except when there is no alternative medication.

2025年1月7日 · Clinicians must remain vigilant to optimize macrolide regimens, balance efficacy with potential toxicities or drug interactions, and uphold stewardship principles for preserving these vital antibiotics.

2024年4月30日 · Macrolides are a class of antibiotics that are commonly used to treat various bacterial infections. They are derived from the macrolide ring, which is a large lactone ring containing 12 to 16 atoms. Macrolides are known for their broad-spectrum activity against a wide range of bacteria, including both Gram-positive and some Gram-negative organisms.

Macrolide, class of antibiotics characterized by their large lactone ring structures and by their growth-inhibiting (bacteriostatic) effects on bacteria. The macrolides were first discovered in the 1950s, when scientists isolated erythromycin from the soil bacterium Streptomyces erythraeus.