In biochemistry, a phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. [1]

2021年11月4日 · Alkaline phosphatase (ALP) is an enzyme that exists throughout your body. High levels of ALP in your blood may indicate liver disease or certain bone disorders.

2023年11月1日 · The alkaline phosphatase test is a common blood test that helps diagnose liver and bone disorders. Learn about its uses, procedure, and normal range.

2024年8月3日 · Alkaline phosphatase (ALP) is an enzyme used as a marker for diseases of the liver, bone, and other organs. Low ALP levels can be a sign of thyroid disease, malnutrition, and more.

An alkaline phosphatase (ALP) test measures the amount of ALP in your blood. ALP is an enzyme, a protein that speeds up certain chemical reactions in your body. ALP is found in all your body tissues, but higher amounts can be found in your liver, bile ducts, and bones.

2020年8月20日 · Alkaline phosphatases (ALPs) are a group of isoenzymes located on the outer layer of the cell membrane. They catalyze the hydrolysis of organic phosphate esters found in the extracellular space. Zinc and magnesium are essential cofactors of this enzyme.

There are three main families of phosphatases, phospho-Tyr phosphatases (PTP), the phospho-Ser/Thr phosphatases, and those that cleave both. Of all phosphorylation sites, most (86%) are on serine, 12% involve threonine and about 2% are on tyrosine. They can also be categorized by molecular sizes, inhibitors, divalent cation requirements, etc.

The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase) is a phosphatase with the physiological role of dephosphorylating compounds.

Alkaline phosphatase (ALP; E.C.3.I.3.1.) is an ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values.

Alkaline phosphatase may be derived from several sites including the liver, bone, third trimester placenta, intestine, and kidneys. An elevation in alkaline phosphatase with a normal gamma-glutamyl transpeptidase or 5'-nucleotidase suggests a nonhepatic source of alkaline phosphatase.